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butabarbital, calcium/magnesium/potassium/sodium oxybates. Either boosts consequences of another by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated as a result of additive CNS melancholy.

These agents must only be mixed if different procedure choices are inadequate. If put together, limit the dosages and length of each drug. Think about therapy modification

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Other side effects not outlined can also arise in a few sufferers. For those who see any other effects, check along with your healthcare Expert.

Perampanel: May possibly greatly enhance the CNS depressant effect of CNS Depressants. Management: Sufferers getting perampanel with some other drug which includes CNS depressant routines should keep away from complex and substantial-risk routines, significantly These for example driving that involve alertness and coordination, till they may have knowledge employing The mixture. Take into consideration therapy modification

butabarbital will minimize the extent or result of lorlatinib by get more info affecting hepatic/intestinal enzyme CYP3A4 metabolism.

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butabarbital will lower the level or effect of abiraterone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

butabarbital will lower the level or outcome of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

butabarbital will reduce the level or influence of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

butabarbital will reduce the extent or effect of solifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

butabarbital will reduce the level or impact of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Importance Unidentified.

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butabarbital boosts results of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may well boost the metabolism of ifosfamide to its Lively alkylating metabolites.